ADC Therapeutics Congress Data Presentations
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ACCP 2023 | POSTERSep 10–12, 2023
A Clinical Quantitative Systems Pharmacolgy Framework Describing Loncastuximab Tesirine Distribution and the Exploration of Patient Outcomes From the LOTIS-2 Clinical Trial in Patients with B-cell Lymphomas
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SOHO 2023 | POSTERSep 6–9, 2023
Updated Results of the Safety Run-In of the Phase 3 LOTIS-5 Trial: Novel Combination of Loncastuximab Tesirine With Rituximab (Lonca-R) Versus Immunochemotherapy in Patients With R/R DLBCL
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SOHO 2023 | POSTERSep 6–9, 2023
Phase 1b open-label study of loncastuximab tesirine in combination with other anticancer agents in patients with relapsed/refractory B-cell non-Hodgkin lymphoma (LOTIS-7)
Encore ASCO 2023
Encore ASCO 2023
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ICML 2023 | ORAL PRESENTATIONJun 13–17, 2023
Long-Term Responses With Loncastuximab Tesirine: Updated Results From LOTIS-2, the Pivotal Phase 2 Study of Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
EHA 2023 Encore
EHA 2023 Encore
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EHA 2023 | POSTERJun 9–12, 2023
Long-Term Responses With Loncastuximab Tesirine: Updated Results From LOTIS-2, the Pivotal Phase 2 Study of Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
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ASCO 2023 | POSTERJun 2–6, 2023
Phase 1b open-label study of loncastuximab tesirine in combination with other anticancer agents in patients with relapsed/refractory B-cell non-Hodgkin lymphoma (LOTIS-7)
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AACR 2023 | POSTERApr 14–19, 2023
Preclinical development of ADCT-211, a novel pyrrolobenzodiazepine dimer-based antibody-drug conjugate targeting solid tumors expressing IL13RA2
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AACR 2023 | POSTERApr 14–19, 2023
Preclinical development of ADCT-212, a PSMA-targeted antibody-drug conjugate employing the pyrrolobenzodiazepine dimer SG2000 for PSMA-expressing cancers
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AACR 2023 | POSTERApr 14–19, 2023
Discovery of plasma protein biomarkers associated with overall survival in R/R DLBCL patients treated with loncastuximab tesirine
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AACR 2023 | POSTERApr 14–19, 2023
A Phase 1/2 Randomized Study of Imvotamab Monotherapy and in Combination with Loncastuximab Tesirine in Relapsed/Refractory Non-Hodgkin Lymphomas
Collaboration
Collaboration
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ASH 2022 | POSTERDec 10–13, 2022
Identification of predictive biomarkers for response of R/R DLBCL patients treated with loncastuximab tesirine using low-pass whole-genome cell-free DNA sequencing (cfDNA-WGS)
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ASH 2022 | POSTERDec 10–13, 2022
Exploratory Analysis of Factors Influencing Efficacy and Safety of Camidanlumab Tesirine: Data From the Open-Label, Multicenter, Phase 2 Study of Patients With R/R cHL
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ASH 2022 | POSTERDec 10–13, 2022
A Phase 2, Open-Label Study of Loncastuximab Tesirine in Combination With Rituximab in Previously Untreated Unfit/Frail Patients With DLBCL (LOTIS-9)
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ASH 2022 | POSTERDec 10–13, 2022
Real-world Outcomes in Relapse/Refractory DLBCL Patients Who Received Polatuzumab
Vedotin Plus Bendamustine and Rituximab or Tafasitamab Plus Lenalidomide by Line of Therapy
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ASH 2022 | POSTERDec 10–13, 2022
Development of Anti-CD45 Antibody Drug Conjugates As Targeted Conditioning Agents for Transplantation/Gene Therapy with Potent Anti-Leukemic Properties. “is not available at this time”
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ASH 2022 | POSTERDec 10–13, 2022
CD19 Expression by IHC Alone Is Not a Predictor of Response to Loncastuximab Tesirine: Results From LOTIS-2 and Quantitative Systems Pharmacology Modeling
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ASH 2022 | POSTERDec 10–13, 2022
CD25, Soluble CD25, and CCL17 as Potential Predictors of Clinical Response to Camidanlumab Tesirine in Patients With R/R Classical HL
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ASH 2022 | ORAL PRESENTATIONDec 10–13, 2022
Real‐World Effectiveness and Economic Impact Associated with Chimeric Antigen Receptor T‐cell Therapy Among Older Patients with
Relapsed/Refractory Diffuse Large B‐Cell Lymphoma in US
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ASH 2022 | ORAL PRESENTATIONDec 10–13, 2022
ADCT-602, a CD22 Targeting Antibody Drug Conjugate Bound to PBD Toxin in Adult Patients with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia A Phase 1 Trial
Independent
Independent
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SOHO 2022 | ORAL PRESENTATIONSep 28–Oct 1, 2022
Camidanlumab tesirine: updated efficacy and safety in an open-label, multicenter, phase 2 study of patients with relapsed or refractory classical Hodgkin lymphoma (R/R cHL)
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SOHO 2022 | POSTERSep 28–Oct 1, 2022
Camidanlumab Tesirine: Updated Efficacy and Safety in an Open-Label, Multicenter, Phase 2 Study of Patients With Relapsed or Refractory Classical Hodgkin Lymphoma (R/R cHL)
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SOHO 2022 | POSTERSep 28–Oct 1, 2022
Long-Term Survival Projections of Loncastuximab Tesirine‒Treated Patients in Relapsed or Refractory Diffuse Large B-cell Lymphoma
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SOHO 2022 | POSTERSep 28–Oct 1, 2022
Initial Safety Run-In Results of the Phase 3 LOTIS-5 Trial: Novel Combination of Loncastuximab Tesirine With Rituximab (Lonca-R) Versus Immunochemotherapy in Patients With R/R DLBCL
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SOHO 2022 | POSTERSep 28–Oct 1, 2022
Health-Related Quality of Life and Tolerability in Patients With/Without Skin Toxicity During Loncastuximab Tesirine Treatment in a Phase 2 Clinical Trial (LOTIS-2)
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SOHO 2022 | POSTERSep 28–Oct 1, 2022
A Phase 2, Open-Label Study of Loncastuximab Tesirine in Combination With Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Patients With Diffuse Large B-cell Lymphoma (DLBCL) (LOTIS-9)
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EHA 2022 | POSTERJun 9–17, 2022
Real-World characteristics and clinical outcomes in relapse/refractory diffuse large B-Cell lymphoma post CAR-T failure
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EHA 2022 | POSTERJun 9–17, 2022
Real-World characteristics and clinical outcomes in relapse/refractory diffuse large B-Cell lymphoma patients who received CAR-T therapy
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EHA 2022 | POSTERJun 9–17, 2022
Health-Related Quality of Life and Tolerability of Loncastuximab Tesirine in High-Risk Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma Treated in a Phase 2 Clinical Trial (LOTIS-2)
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EHA 2022 | ORAL PRESENTATIONJun 9–17, 2022
Camidanlumab tesirine: updated efficacy and safety in an
open‐label, multicenter, phase 2 study of patients with relapsed
or refractory classical Hodgkin lymphoma (R/R cHL)
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ASCO 2022 | POSTERJun 3–7, 2022
Phase 3 Randomized Study of Loncastuximab Tesirine in Combination With Rituximab (Lonca-R) Versus Immunochemotherapy in Patients With R/R DLBCL (LOTIS-5)
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ASCO 2022 | POSTERJun 3–7, 2022
First-in-Human, Phase 1, Open-Label, Dose-Escalation
Study of ADCT-901 as Monotherapy in Patients With Select
Advanced Solid Tumors
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ONS 2022 | POSTERApr 27–May 1, 2022
Characterization and Management of Cutaneous Reactions in Patients With Relapsed or Refractory
Diffuse Large B-Cell Lymphoma Treated With Loncastuximab Tesirine in the LOTIS-2 Trial
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ONS 2022 | POSTERApr 27–May 1, 2022
Onset, Duration, and Management of Edema and Effusion in Patients Treated With
Loncastuximab Tesirine for R/R DLBCL: Updated Results From the LOTIS-2 Clinical Trial
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AACR 2022 | POSTERApr 8–13, 2022
AXL as a therapeutic target in adenoid cystic carcinoma: preclinical evaluation of AXL targeting antibody-drug conjugate (ADCT-601)
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AACR 2022 | POSTERApr 8–13, 2022
Mechanistic studies investigating the synergistic combination of Loncastuximab Tesirine and Ibrutinib in pre-clinical models of B-Cell non-Hodgkin lymphoma
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AACR 2022 | POSTERApr 8–13, 2022
Effect of Camidanlumab Tesirine (Cami) as Monotherapy and in Combination With Pembrolizumab
(PEM) on the Immune Cell Profile in Patients With Selected Advanced Solid Tumors
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NCCN 2022 | POSTERMar 31–Apr 2, 2022
Health-Related Quality of Life, Symptoms, and Tolerability of Loncastuximab Tesirine in Older Versus Younger Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma Treated in a Phase 2 Clinical Trial (LOTIS-2)
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HOPA 2022 | POSTERMar 30–Apr 2, 2022
A Pooled Safety Analysis of Loncastuximab Tesirine in R/R DLBCL in the LOTIS Clinical Trial Program: Incidence, Onset, and Management of Myelosuppression
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ASH 2021 | POSTERDec 11–14, 2021
Clinical Characteristics and Responses of Patients With
Relapsed or Refractory High-Grade B-Cell Lymphoma Treated
With Loncastuximab Tesirine in the LOTIS-2 Clinical Trial
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ASH 2021 | ORAL PRESENTATIONDec 11–14, 2021
Planned Interim Analysis of a Phase 2 Study of Loncastuximab Tesirine Plus Ibrutinib in Patients with Advanced Diffuse Large B‐Cell Lymphoma (LOTIS‐3)
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ASH 2021 | POSTERDec 11–14, 2021
Clinical Characteristics and Responses of Patients with Relapsed or Refractory High‐Grade B‐Cell Lymphoma Treated with Loncastuximab Tesirine in the LOTIS‐2 Clinical Trial
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AMCP Nexus 2021 | POSTEROct 19–22, 2021
Budget Impact Model for Loncastuximab Tesirine-lpyl in the Treatment of Relapsed/Refractory Diffuse Large B-cell Lymphoma
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SOHO 2021 | POSTERSep 8–11, 2021
Incidence, onset, and management of edema and effusion in patients treated with loncastuximab tesirine for R/R DLBCL in the LOTIS clinical trial program
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SOHO 2021 | ORAL PRESENTATIONSep 8–11, 2021
LOTIS-2 follow-up analysis: Updated results from a Phase 2 study of loncastuximab tesirine in relapsed or refractory diffuse large B-Cell lymphoma
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SOHO 2021 | ORAL PRESENTATIONSep 8–11, 2021
LOTIS-2 follow-up analysis: Updated results from a Phase 2 study of loncastuximab tesirine in relapsed or refractory diffuse large B-Cell lymphoma
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SOHO 2021 | POSTERSep 8–11, 2021
Incidence, onset, and management of myelosuppression in patients treated with loncastuximab tesirine for R/R DLBCL in a pooled safety analysis
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ICML 2021 | POSTERJun 18–22, 2021
A Phase 2 randomized study of loncastuximab tesirine (Lonca) vs idelalisib in patients with relapsed or refractory (R/R) follicular lymphoma (FL) — LOTIS-6
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ICML 2021 | POSTERJun 18–22, 2021
A Phase 3 randomized study of loncastuximab tesirine plus rituximab vs immunochemotherapy in patients with relapsed/refractory diffuse large B-Cell lymphoma — LOTIS-5
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ICML 2021 | POSTERJun 18–22, 2021
LOTIS-2 follow-up analysis: Updated results from a Phase 2 study of loncastuximab tesirine in relapsed
or refractory diffuse large B-Cell lymphoma
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ICML 2021 | ORAL PRESENTATIONJun 18–22, 2021
Camidanlumab tesirine efficacy and safety in an open-label, multicenter, Phase 2 study of patients with relapsed or refractory classical Hodgkin lymphoma (R/R cHL)
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ICML 2021 | POSTERJun 18–22, 2021
Clinical activity of loncastuximab tesirine plus ibrutinib in non-Hodgkin lymphoma: Updated LOTIS-3 Phase 1 results
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EHA 2021-2012 | POSTERJun 9, 2021–Jun 17, 2012
Duration of Response to Loncastuximab Tesirine in Relapsed/Refractory Diffuse Large B-cell Lymphoma by Demographic and Clinical Characteristics: Subgroup Analyses from LOTIS-2
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EHA 2021-2012 | POSTERJun 9, 2021–Jun 17, 2012
CHARACTERISTICS AND OUTCOMES IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA WHO RECEIVED ≥3 LINES OF THERAPIES
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ASCO 2021 | POSTERJun 4–8, 2021
Phase 3 Randomized Study of Lonca plus Rituximab versus Immunochemotherapy in Patients with RR DLBCL LOTIS
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ASCO 2021 | POSTERJun 4–8, 2021
Duration of Response to Lonca RR DLBCL by Demographic Subgroup Analysis from LOTIS
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ASCO 2021 | POSTERJun 4–8, 2021
A Phase 1b, Open-Label, Dose-Escalation Study to Evaluate Camidanlumab Tesirine (Cami) as Monotherapy in Patients with Advanced Solid Tumors
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AACR 2021 | POSTERApr 10–15, 2021
Integrated Population Modeling of Loncastuximab Tesirine (Lonca) Exposure in B-cell Non-Hodgkin Lymphoma (B-NHL)
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AACR 2021 | POSTERApr 10–15, 2021
Relationship Between Exposure and Safety/Efficacy of Loncastuximab Tesirine in B-cell Non-Hodgkin Lymphoma
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ASH 2020 | POSTERDec 5–8, 2020
Efficacy and Safety of Loncastuximab Tesirine (ADCT-402) in
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
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ASH 2020 | POSTERDec 5–8, 2020
Safety and Antitumor Activity Study Evaluating Loncastuximab Tesirine and
Rituximab Versus Immunochemotherapy in Diffuse Large B-Cell Lymphoma
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ASH 2020 | POSTERDec 5–8, 2020
Analysis of ADCT-602 Pre-Clinical Activity in B-Cell Lymphoma Models and
Identification of Potential Biomarkers for Its Activity
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ASH 2020 | POSTERDec 5–8, 2020
Preliminary Results of a Phase 2 Study of Camidanlumab Tesirine (Cami), a
Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients
With Relapsed or Refractory Hodgkin Lymphoma
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ASH 2020 | POSTERDec 5–8, 2020
Combination of Camidanlumab Tesirine, a CD25-Targeted ADC, with
Gemcitabine Elicits Synergistic Anti-Tumor Activity in Preclinical Tumor Models
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ASH 2020 | POSTERDec 5–8, 2020
Pharmacokinetic and Pharmacodynamic Correlates From the Phase 1
Study of Camidanlumab Tesirine (Cami) in Patients With Relapsed or
Refractory Hodgkin Lymphoma and Non-Hodgkin Lymphoma
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SITC 2020 | POSTERNov 11–14, 2020
A Tregs-depleting CD25-targeted antibody-drug conjugate synergizes with tumor-targeted radiotherapy and systemic interleukin-2 in pre-clinical models of solid cancers
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ESMO 2020 | POSTERSep 19–21, 2020
First-in-Human Study of Camidanlumab Tesirine (ADCT-301, Cami), an anti-CD25 Targeted Therapy in Patients (Pts) with Advanced Solid Tumors: Pharmacokinetics (PK) and Biomarker Evaluation
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EHA 2020 | ORAL PRESENTATIONJun 11–21, 2020
Initial Results of a Phase 2 Study of Loncastuximab Tesirine, a Novel
Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients
With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
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EHA 2020 | POSTERJun 11–21, 2020
Interim results of a phase 1/2 study of loncastuximab tesirine (Lonca) combined with ibrutinib in advanced diffuse large B-cell lymphoma (DLBCL) or mantle cell lymphoma (MCL)
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ASH 2019 | PRESENTATIONDec 7–10, 2019
Interim Futility Analysis of a Phase 2 Study of Loncastuximab Tesirine, a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
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SITC 2019 | POSTERNov 7–10, 2019
Pre-clinical characterization of the mechanism of action of a CD25-targeted pyrrolobenzodiazepine dimer-based antibody-drug conjugate targeting regulatory T cells in solid cancers
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ESMO 2019 | POSTERSep 27–Oct 1, 2019
A Phase 1, Open-label, Dose-Escalation Study to Evaluate the Safety,
Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT-601 in
Patients with Advanced Solid Tumors
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ICML 2019 | ORAL PRESENTATIONJun 18–23, 2019
Analysis of Efficacy and Safety of Loncastuximab Tesirine
(ADCT-402) by Demographic and Clinical Characteristics in
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
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ICML 2019 | ORAL PRESENTATIONJun 18–23, 2019
The Antibody-Drug Conjugate (ADC) Loncastuximab Tesirine (ADCT 402)
Targeting CD19 Shows Strong in vitro Anti-Lymphoma Activity Both As Single
Agents and in Combination
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ICML 2019 | ORAL PRESENTATIONJun 18–23, 2019
Analysis of Clinical Determinants Driving Safety and Efficacy
of Camidanlumab Tesirine (ADCT-301, Cami) in
Relapsed/Refractory (R/R) Classical Hodgkin Lymphoma (cHL)
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ICML 2019 | POSTERJun 18–23, 2019
The anti-CD25 antibody-drug conjugate camidanlumab tesirine (ADCT-301) presents a strong preclinical activity both as single agent and in combination in lymphoma cell lines
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AACR 2019 | POSTERMar 29–Apr 3, 2019
Pre-clinical characterization of 3A4-PL1601, a novel pyrrolobenzodiazepine (PBD) dimer-based antibody-drug conjugate (ADC) directed against KAAG1-expressing malignancies
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ASH 2018 | PRESENTATIONDec 1–4, 2018
Phase 1 Study of ADCT-301 (Camidanlumab Tesirine), a Novel
Pyrrolobenzodiazepine-Based Antibody Drug Conjugate, in
Relapsed/Refractory Classical Hodgkin Lymphoma
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SITC 2018 | POSTERNov 9–11, 2018
A CD25-targeted pyrrolobenzodiazepine dimer-based antibody-drug conjugate shows potent anti-tumor activity in pre-clinical models of solid tumors either alone or in combination with a PD-1 inhibitor
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AACR 2018 | POSTERApr 14–18, 2018
Pre-clinical activity of ADCT-601, a novel pyrrolobenzodiazepine (PBD) dimer-based antibody-drug conjugate (ADC) targeting AXL-expressing tumors
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AACR 2018 | POSTERApr 14–18, 2018
ADCT-701, a novel pyrrolobenzodiazepine (PBD) dimer-based antibody-drug conjugate (ADC) targeting DLK1-expressing tumors
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ASH 2017 | POSTERDec 9–12, 2017
Elucidating Exposure-Response (Safety and Efficacy) of ADCT-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Containing Antibody Drug Conjugate, for Recommended Phase 2
Dose Determination in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma
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ASH 2017 | POSTERDec 9–12, 2017
Results from an Ongoing Phase 1 Study Indicate ADCT-301 (Camidanlumab Tesirine) Is Well Tolerated in Patients with Relapsed or Refractory CD25-Positive Acute Leukemia
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AACR 2017 | POSTERApr 1–5, 2017
Characterization of the mechanism of action, pharmacodynamics and preclinical safety of ADCT-402, no. 51 a pyrrolobenzodiazepine (PBD) dimer-containing antibody-drug conjugate (ADC) targeting CD19-expressing hematological malignancies
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ASH 2016 | POSTERDec 3–6, 2016
ADCT-602 (hLL2-cys-PBD), a new site-specifically conjugated, pyrrolobenzodiazepine (PBD) dimer-based antibody drug conjugate (ADC) targeting CD22-expressing B-cell malignancies
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ASCO 2016 | POSTERJun 3–7, 2016
A phase 1 dose-escalation study to evaluate the tolerability, safety, pharmacokinetics, and antitumor activity of ADCT-402 in patients with relapsed or refractory B-Cell lineage non-Hodgkin lymphoma (B-NHL)
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AACR 2015 | POSTERApr 18–22, 2015
Pre-clinical Activity of hLL2-PBD, a Novel Anti-CD22 Antibody-Pyrrolobenzodiazepine (PBD) Conjugate in Models of Non-Hodgkin Lymphoma
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