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ADC Therapeutics Congress Data Presentations

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AACR 2022 | POSTERApr 8–13, 2022
AXL as a therapeutic target in adenoid cystic carcinoma: preclinical evaluation of AXL targeting antibody-drug conjugate (ADCT-601)
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AACR 2022 | POSTERApr 8–13, 2022
Mechanistic studies investigating the synergistic combination of Loncastuximab Tesirine and Ibrutinib in pre-clinical models of B-cell non-Hodgkin lymphoma
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AACR 2022 | POSTERApr 8–13, 2022
Effect of Camidanlumab Tesirine (Cami) as Monotherapy and in Combination With Pembrolizumab (PEM) on the Immune Cell Profile in Patients With Selected Advanced Solid Tumors
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ASH 2021 | POSTERDec 11–14, 2021
Phase 1 Trial of ADCT-602, a CD22 Targeting ADC Bound to PBD Toxin in Adult Patients With RR CD22+ B-Cell ALL
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ASH 2021 | POSTERDec 11–14, 2021
CD19-Mediated DNA Damage Boost in Lymphoma Cells Treated With Loncastuximab Tesirine in Combination with PARP Inhibitors
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ASH 2021 | POSTERDec 11–14, 2021
The Anti-CD19 Antibody-Drug Conjugate Loncastuximab Tesirine Achieved Responses in Patients With Diffuse Large B-cell Lymphoma Who Relapsed After Anti-CD19 CAR T-Cell Therapy
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ASH 2021 | POSTERDec 11–14, 2021
Combination of Loncastuximab Tesirine and Polatuzumab Vedotin Shows Increased Anti-Tumor Activity in Pre-Clinical Models of Non-Hodgkin Lymphoma
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ASH 2021 | POSTERDec 11–14, 2021
Clinical Characteristics and Responses of Patients With Relapsed or Refractory High-Grade B-cell Lymphoma Treated With Loncastuximab Tesirine in the LOTIS-2 Clinical Trial
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ASH 2021 | POSTERDec 11–14, 2021
American Society of Hematology (ASH)
United States
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ISPOR EU 2021 | POSTERDec 1–3, 2021
International Society for Pharmacoeconomics & Outcomes Research (ISPOR EU)
Virtual
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SITC 2021 | POSTERNov 10–14, 2021
Society for Immunotherapy of Cancer (SITC)
Washington, D.C.
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AMCP Nexus 2021 | POSTEROct 19–22, 2021
Academy of Managed Care Pharmacy (AMCP Nexus)
Denver, CO
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ESMO 2021 | POSTERSep 17–21, 2021
European Society for Medical Oncology (ESMO)
Paris, France
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ACCP 2021 | POSTERSep 12–14, 2021
American College of Clinical Pharmacy (ACCP)
Phoenix, AZ
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SOHO 2021 | POSTERSep 8–11, 2021
Incidence, onset, and management of edema and effusion in patients treated with loncastuximab tesirine for R/R DLBCL in the LOTIS clinical trial program
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SOHO 2021 | POSTERSep 8–11, 2021
LOTIS-2 follow-up analysis: Updated results from a Phase 2 study of loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma
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SOHO 2021 | POSTERSep 8–11, 2021
LOTIS-2 follow-up analysis: Updated results from a Phase 2 study of loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma
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SOHO 2021 | POSTERSep 8–11, 2021
Incidence, onset, and management of myelosuppression in patients treated with loncastuximab tesirine for R/R DLBCL in a pooled safety analysis
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ICML 2021 | POSTERJun 18–22, 2021
A Phase 2 randomized study of loncastuximab tesirine (Lonca) vs idelalisib in patients with relapsed or refractory (R/R) follicular lymphoma (FL) — LOTIS-6
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ICML 2021 | POSTERJun 18–22, 2021
A Phase 3 randomized study of loncastuximab tesirine plus rituximab vs immunochemotherapy in patients with relapsed/refractory diffuse large B-cell lymphoma — LOTIS-5
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ICML 2021 | POSTERJun 18–22, 2021
LOTIS-2 follow-up analysis: Updated results from a Phase 2 study of loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma
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ICML 2021 | POSTERJun 18–22, 2021
Camidanlumab tesirine efficacy and safety in an open-label, multicenter, Phase 2 study of patients with relapsed or refractory classical Hodgkin lymphoma (R/R cHL)
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EHA 2021 | POSTERJun 10–13, 2021
European Hematology Association (EHA)
Vienna, Austria
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ASCO 2021 | POSTERJun 4–8, 2021
Phase 3 Randomized Study of Lonca plus Rituximab versus Immunochemotherapy in Patients with RR DLBCL LOTIS
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ASCO 2021 | POSTERJun 4–8, 2021
Duration of Response to Lonca RR DLBCL by Demographic Subgroup Analysis from LOTIS
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ISPOR 2021 | POSTERMay 15–19, 2021
International Society for Pharmacoeconomics & Outcomes Research (ISPOR)
Montreal, QC, Canada
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ASH 2020 | POSTERDec 5–8, 2020
Efficacy and Safety of Loncastuximab Tesirine (ADCT-402) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma
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ASH 2020 | POSTERDec 5–8, 2020
Safety and Antitumor Activity Study Evaluating Loncastuximab Tesirine and Rituximab Versus Immunochemotherapy in Diffuse Large B-Cell Lymphoma
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ASH 2020 | POSTERDec 5–8, 2020
Analysis of ADCT-602 Pre-Clinical Activity in B-Cell Lymphoma Models and Identification of Potential Biomarkers for Its Activity
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ASH 2020 | POSTERDec 5–8, 2020
Preliminary Results of a Phase 2 Study of Camidanlumab Tesirine (Cami), a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients With Relapsed or Refractory Hodgkin Lymphoma
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ASH 2020 | POSTERDec 5–8, 2020
Combination of Camidanlumab Tesirine, a CD25-Targeted ADC, with Gemcitabine Elicits Synergistic Anti-Tumor Activity in Preclinical Tumor Models
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ASH 2020 | POSTERDec 5–8, 2020
Pharmacokinetic and Pharmacodynamic Correlates From the Phase 1 Study of Camidanlumab Tesirine (Cami) in Patients With Relapsed or Refractory Hodgkin Lymphoma and Non-Hodgkin Lymphoma
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ESMO 2020 | POSTERSep 19–21, 2020
First-in-Human Study of Camidanlumab Tesirine (ADCT-301, Cami), an anti-CD25 Targeted Therapy in Patients (Pts) with Advanced Solid Tumors: Pharmacokinetics (PK) and Biomarker Evaluation
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EHA 2020 | PRESENTATIONJun 11–21, 2020
Initial Results of a Phase 2 Study of Loncastuximab Tesirine, a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
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EHA 2020 | POSTERJun 11–21, 2020
Interim Results of a Phase 1/2 Study of Loncastuximab Tesirine (Lonca) Combined with Ibrutinib in Advanced Diffuse Large B-Cell Lymphoma (DLBCL) or Mantle Cell Lymphoma (MCL)
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ASH 2019 | PRESENTATIONDec 7–10, 2019
Interim Futility Analysis of a Phase 2 Study of Loncastuximab Tesirine, a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
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ESMO 2019 | POSTERSep 27–Oct 1, 2019
A Phase 1, Open-label, Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT-601 in Patients with Advanced Solid Tumors
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ICML 2019 | PRESENTATIONJun 18–23, 2019
Analysis of Efficacy and Safety of Loncastuximab Tesirine (ADCT-402) by Demographic and Clinical Characteristics in Relapsed/Refractory Diffuse Large B-Cell Lymphoma
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ICML 2019 | PRESENTATIONJun 18–23, 2019
The Antibody-Drug Conjugate (ADC) Loncastuximab Tesirine (ADCT 402) Targeting CD19 Shows Strong in vitro Anti-Lymphoma Activity Both As Single Agents and in Combination
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ICML 2019 | PRESENTATIONJun 18–23, 2019
Analysis of Clinical Determinants Driving Safety and Efficacy of Camidanlumab Tesirine (ADCT-301, Cami) in Relapsed/Refractory (R/R) Classical Hodgkin Lymphoma (cHL)
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ICML 2019 | POSTERJun 18–23, 2019
The anti-CD25 antibody-drug conjugate camidanlumab tesirine (ADCT-301) presents a strong preclinical activity both as single agent and in combination in lymphoma cell lines
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ASH 2018 | PRESENTATIONDec 1–4, 2018
Phase 1 Study of ADCT-301 (Camidanlumab Tesirine), a Novel Pyrrolobenzodiazepine-Based Antibody Drug Conjugate, in Relapsed/Refractory Classical Hodgkin Lymphoma
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SITC 2018 | POSTERNov 9–11, 2018
A CD25-targeted pyrrolobenzodiazepine dimer-based antibody-drug conjugate shows potent anti-tumor activity in pre-clinical models of solid tumors either alone or in combination with a PD-1 inhibitor
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AACR 2018 | POSTERApr 14–18, 2018
Pre-clinical activity of ADCT-601, a novel pyrrolobenzodiazepine (PBD) dimer-based antibody-drug conjugate (ADC) targeting AXL-expressing tumors
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AACR 2018 | POSTERApr 14–18, 2018
ADCT-701, a novel pyrrolobenzodiazepine (PBD) dimer-based antibody-drug conjugate (ADC) targeting DLK1-expressing tumors
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ASH 2017 | POSTERDec 9–12, 2017
Elucidating Exposure-Response (Safety and Efficacy) of ADCT-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Containing Antibody Drug Conjugate, for Recommended Phase 2 Dose Determination in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma
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ASH 2017 | POSTERDec 9–12, 2017
Results from an Ongoing Phase 1 Study Indicate ADCT-301 (Camidanlumab Tesirine) Is Well Tolerated in Patients with Relapsed or Refractory CD25-Positive Acute Leukemia
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AACR 2017 | POSTERApr 1–5, 2017
Characterization of the mechanism of action, pharmacodynamics and preclinical safety of ADCT-402, no. 51 a pyrrolobenzodiazepine (PBD) dimer-containing antibody-drug conjugate (ADC) targeting CD19-expressing hematological malignancies
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ASH 2016 | POSTERDec 3–6, 2016
ADCT-602 (hLL2-cys-PBD), a new site-specifically conjugated, pyrrolobenzodiazepine (PBD) dimer-based antibody drug conjugate (ADC) targeting CD22-expressing B-cell malignancies
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ASCO 2016 | POSTERJun 3–7, 2016
A phase 1 dose-escalation study to evaluate the tolerability, safety, pharmacokinetics, and antitumor activity of ADCT-402 in patients with relapsed or refractory B-cell lineage non-Hodgkin lymphoma (B-NHL)
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AACR 2015 | POSTERApr 18–22, 2015
Pre-clinical Activity of hLL2-PBD, a Novel Anti-CD22 Antibody-Pyrrolobenzodiazepine (PBD) Conjugate in Models of Non-Hodgkin Lymphoma
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